Objectives: Chronic suppurative otitis media commonly caused by bacterial infection however with the\udcommencement of antibiotics, the otorrhea would always resolved within a short period of time. The\udaim of this study was to look at the involvement of fungus in CSOM with persistent otorrhea and association\udbetween topical antibiotic eardrop with fungal infection in CSOM.\udMethods: Sixty-two patients were included in this cross sectional study which was carried out in\udOtorhinolaryngology clinic Hospital Universiti Sains Malaysia. All CSOM patients with persistent otorrhea\udfor at least two weeks were included in this study. Patient with otomycosis, intact tympanic membrane,\udotitis externa and cholesteatoma were excluded from the study.\udThe swab samples for bacterial and fungal culture were collected under aseptic precautions. Ofloxacin\udeardrop were prescribed to all patients for two weeks. The patients were advised to strictly clean the\udear canal before applying the ear drops and to keep the ear dry. After two weeks, if there were persistent\udear discharge, swab for fungal culture and bacterial study were repeated.\udResults: The incidence of fungal infection was 6.4% (4/62). The fungi isolated were Aspergillus, Candida\udand Penicillium species. Majority cases of otorrhea cultured bacteria. There was no association of fungal\udinfection and topical antibiotics instead we found ofloxacin to be an effective medication in treating otorrhea.\udConclusion: The incident of fungal colonization in persistent otorrhea is low (7%). The fungal isolated\udwere Aspergillus flavus, Candida parapsilosis and Penicillium spp. Bacteria are still the most common\udmicroorganism in persistent otorrhea.
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